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- Title
Psychostimulant effect of levodopa: reversing sensitisation is possible.
- Authors
Castrioto, Anna; Kistner, Andrea; Klinger, Hélène; Lhommée, Eugénie; Schmitt, Emmanuelle; Fraix, Valérie; Chabardès, Stephan; Mertens, Patrick; Quesada, Jean-Louis; Broussolle, Emmanuel; Pollak, Pierre; Thobois, Stéphane C; Krack, Paul
- Abstract
Levodopa therapy in Parkinson's disease (PD) is associated with non-motor complications resulting from sensitisation of the ventral striatum system. Recent studies showed an improvement in non-motor complications in PD patients with subthalamic stimulation. We hypothesised that ventral striatum desensitisation might contribute to this improvement.
- Publication
Journal of neurology, neurosurgery, and psychiatry, 2013, Vol 84, Issue 1, p18
- ISSN
1468-330X
- Publication type
Journal Article
- DOI
10.1136/jnnp-2012-302444