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- Title
Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability.
- Authors
Pagnamenta, Alistair T; Khan, Hameed; Walker, Susan; Gerrelli, Dianne; Wing, Kirsty; Bonaglia, Maria Clara; Giorda, Roberto; Berney, Tom; Mani, Elisa; Molteni, Massimo; Pinto, Dalila; Le Couteur, Ann; Hallmayer, Joachim; Sutcliffe, James S; Szatmari, Peter; Paterson, Andrew D; Scherer, Stephen W; Vieland, Veronica J; Monaco, Anthony P
- Abstract
Autism spectrum disorder (ASD) is characterised by impairments in social communication and by a pattern of repetitive behaviours, with learning disability (LD) typically seen in up to 70% of cases. A recent study using the PPL statistical framework identified a novel region of genetic linkage on chromosome 16q21 that is limited to ASD families with LD.
- Publication
Journal of medical genetics, 2011, Vol 48, Issue 1, p48
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmg.2010.079426