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- Title
Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors.
- Authors
Futter, M; Diekmann, H; Schoenmakers, E; Sadiq, O; Chatterjee, K; Rubinsztein, D C
- Abstract
Huntington's disease is caused by expansion of a polyglutamine tract found in the amino-terminal of the ubiquitously expressed protein huntingtin. Well studied in its mutant form, huntingtin has a wide variety of normal functions, loss of which may also contribute to disease progression. Widespread transcriptional dysfunction occurs in brains of Huntington's disease patients and in transgenic mouse and cell models of Huntington's disease.
- Publication
Journal of medical genetics, 2009, Vol 46, Issue 7, p438
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmg.2009.066399