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- Title
Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.
- Authors
Francis, P J; Hamon, S C; Ott, J; Weleber, R G; Klein, M L
- Abstract
Age related macular degeneration (AMD) is a leading cause of blindness. AMD is a complex disorder caused by genetic and environmental factors in which single nucleotide polymorphisms (SNPs) in the genes CFH and LOC387715/HTRA1/ARMS2 have prognostic importance for progression to advanced AMD (with visual loss). CFH may also have a pharmacogenetic role by affecting treatment response to widely used nutritional supplements. This paper examines other AMD susceptibility genes to determine if these genotypes influenced disease progression and treatment response.
- Publication
Journal of medical genetics, 2009, Vol 46, Issue 5, p300
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmg.2008.062737