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- Title
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype.
- Authors
Lambrechts, D; Poesen, K; Fernández-Santiago, R; Al-Chalabi, A; Del Bo, R; Van Vught, P W J; Khan, S; Marklund, S L; Brockington, A; van Marion, I; Anneser, J; Shaw, C; Ludolph, A C; Leigh, N P; Comi, G P; Gasser, T; Shaw, P J; Morrison, K E; Andersen, P M; Van den Berg, L H; Thijs, V; Siddique, T; Robberecht, W; Carmeliet, P
- Abstract
Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), to motor neurons prolongs survival in rodent models of amyotrophic lateral sclerosis (ALS), while mice expressing reduced VEGF concentrations develop motor neuron degeneration reminiscent of ALS, raising the question whether VEGF contributes to the pathogenesis of ALS. An initial association study reported that VEGF haplotypes conferred increased susceptibility to ALS in humans, but later studies challenged this initial finding.
- Publication
Journal of medical genetics, 2009, Vol 46, Issue 12, p840
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmg.2008.058222