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- Title
Large genomic rearrangements of both BRCA2 and BRCA1 are a feature of the inherited breast/ovarian cancer phenotype in selected families.
- Authors
Woodward, A M; Davis, T A; Silva, A G S; Kirk, J A; Leary, J A; kConFab Investigators
- Abstract
A strong family history of breast and/or ovarian cancer can often be explained by small insertions, deletions, or substitutions in BRCA1 or BRCA2 and large genomic rearrangements in BRCA1. However, there is little evidence that genomic rearrangements are a major factor in BRCA2 associated breast cancer and the frequencies of rearrangements in BRCA1 in large clinic based populations are unknown.
- Publication
Journal of medical genetics, 2005, Vol 42, Issue 5, pe31
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmg.2004.027961