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- Title
TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease.
- Authors
Fowler, E V; Eri, R; Hume, G; Johnstone, S; Pandeya, N; Lincoln, D; Templeton, D; Radford-Smith, G L
- Abstract
The cytokines tumour necrosis factor (TNF)alpha and interleukin (IL)10 have been implicated in the pathogenesis of Crohn's disease (CD), with increased concentrations reported in patients with active disease. However, limited data exist on their effects on disease phenotype in the same population. Certain single nucleotide polymorphisms (SNPs) within the promoter region of the IL10 (-1082G/A, -592C/A) and TNFalpha (-308G/A, -857C/T) genes have been associated with altered levels of circulating IL10 and TNFalpha.
- Publication
Journal of medical genetics, 2005, Vol 42, Issue 6, p523
- ISSN
1468-6244
- Publication type
Research
- DOI
10.1136/jmg.2004.027425