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- Title
Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction.
- Authors
Cornelis, M C; El-Sohemy, A; Campos, H
- Abstract
There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by cytochrome P450 (CYP) 1A1 or CYP1A2. The objective of this study was to determine the effects of CYP1A1 and CYP1A2 genotypes on risk of myocardial infarction (MI) and whether smoking interacts with genotype to modify risk.
- Publication
Journal of medical genetics, 2004, Vol 41, Issue 10, p758
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmg.2004.022012