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- Title
Hereditary multiple exostoses: report of a kindred.
- Authors
Gordon, S L; Buchanan, J R; Ladda, R L
- Abstract
In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.
- Publication
Journal of medical genetics, 1981, Vol 18, Issue 6, p428
- ISSN
0022-2593
- Publication type
Journal Article
- DOI
10.1136/jmg.18.6.428