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- Title
Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes.
- Authors
Docherty, Louise E; Rezwan, Faisal I; Poole, Rebecca L; Jagoe, Hannah; Lake, Hannah; Lockett, Gabrielle A; Arshad, Hasan; Wilson, David I; Holloway, John W; Temple, I Karen; Mackay, Deborah J G
- Abstract
Genomic imprinting is allelic restriction of gene expression potential depending on parent of origin, maintained by epigenetic mechanisms including parent of origin-specific DNA methylation. Among approximately 70 known imprinted genes are some causing disorders affecting growth, metabolism and cancer predisposition. Some imprinting disorder patients have hypomethylation of several imprinted loci (HIL) throughout the genome and may have atypically severe clinical features. Here we used array analysis in HIL patients to define patterns of aberrant methylation throughout the genome.
- Publication
Journal of medical genetics, 2014, Vol 51, Issue 4, p229
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmedgenet-2013-102116