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- Title
Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay.
- Authors
Mossner, Maximilian; Nolte, Florian; Hütter, Gero; Reins, Jana; Klaumünzer, Marion; Nowak, Verena; Obländer, Julia; Ackermann, Katrin; Will, Silke; Röhl, Henning; Neumann, Uwe; Neumann, Martin; Hopfer, Olaf; Baldus, Claudia D; Hofmann, Wolf-Karsten; Nowak, Daniel
- Abstract
Investigation of X-chromosome inactivation patterns (XCIP) by determination of differential CpG-methylation has been widely applied for investigation of female cell clonality. Using this approach the clonal origin of various tumours has been corroborated. Controversially, strong age-related increase of peripheral blood (PB) cell clonality in haematologically healthy female subjects was reported. Recently, transcriptional XCIP ratio analysis challenged these results and questioned the suitability of methylation based clonality assays.
- Publication
Journal of medical genetics, 2013, Vol 50, Issue 2, p108
- ISSN
1468-6244
- Publication type
Journal Article
- DOI
10.1136/jmedgenet-2012-101093