We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: computer-assisted intravital microscopy study.
- Authors
Cheung, Anthony T W; Chan, Matthew S; Ramanujam, Sahana; Rangaswami, Arun; Curl, Kris; Franklin, Patricia; Wun, Ted
- Abstract
Nine patients with sickle cell disease (SCD) who were hospitalized at UC Davis Medical Center for vaso-occlusive crisis (VOC) were studied as part of a randomized double-blind phase III clinical trial to investigate the real-time effects of poloxamer 188 on VOC. All patients showed significant microvascular changes from normal (steady-state) values during VOC (diminished venular diameter and red cell velocity). The patients were randomly assigned to be treated with poloxamer 188 or placebo. Poloxamer 188 (n = 4) but not placebo (n = 5) significantly reversed these microvascular changes approximately 2 hours postinitiation of loading infusion (100 mg/kg in 1 hour). Further significant improvement induced by poloxamer 188 but not placebo was observed > or = 7 hours postinfusion, resulting in a significant reversal of the microvascular changes to steady-state values.
- Publication
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2004, Vol 52, Issue 6, p402
- ISSN
1081-5589
- Publication type
Journal Article
- DOI
10.1136/jim-52-06-35