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- Title
Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer.
- Authors
Pillai, M R; Chacko, P; Kesari, L A; Jayaprakash, P G; Jayaram, H N; Antony, A C
- Abstract
Folate receptors (FRs) mediate cellular uptake of folates in many cancer cells and in folate deficiency heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) mediates translational upregulation of FR in cultured cervical cancer cells. hnRNP-E1 can also interfere with human papillomavirus 16 (HPV-16) viral capsid protein synthesis (and thereby HPV proliferation) in vitro. This study aimed to evaluate prospectively the relevance of FR and hnRNP-E1 expression in the normal cervix, cervical dysplasia, and cancer.
- Publication
Journal of clinical pathology, 2003, Vol 56, Issue 8, p569
- ISSN
0021-9746
- Publication type
Journal Article
- DOI
10.1136/jcp.56.8.569