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- Title
Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance.
- Authors
Montironi, R; Mazzucchelli, R; Algaba, F; Lopez-Beltran, A
- Abstract
High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum prostate specific antigen (PSA) or its derivatives, does not induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation decreases the prevalence and extent of PIN, suggesting that this form of treatment might play a role in chemoprevention. Radiotherapy is also associated with a decreased incidence of PIN.
- Publication
Journal of clinical pathology, 2000, Vol 53, Issue 9, p655
- ISSN
0021-9746
- Publication type
Journal Article
- DOI
10.1136/jcp.53.9.655