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- Title
Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation.
- Authors
Matsumura, T; Yamaguchi, T; Tochigi, N; Wada, T; Yamashita, T; Hasegawa, T
- Abstract
Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue tumour of uncertain differentiation and low metastatic potential. Cytogenetics and/or molecular genetics have revealed that most have a rearrangement of the EWSR1 gene, whereas a FUS gene rearrangement is present in a minority of cases. Although some cases of AFH display striking pleomorphism and mitotic activity, there are no known clinical, morphological or genetic factors that predict metastasis. The authors present clinicopathological features of AFH, including cases showing a pleomorphic histological appearance, and results of fluorescence in situ hybridisation analysis of EWSR1 and FUS rearrangements.
- Publication
Journal of clinical pathology, 2010, Vol 63, Issue 2, p124
- ISSN
1472-4146
- Publication type
Journal Article
- DOI
10.1136/jcp.2009.072256