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Title
Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours.
Authors
Aleixo, P B; Hartmann, A A; Menezes, I C; Meurer, R T; Oliveira, A M
Abstract
Well differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) have been shown to have supernumerary chromosomes with amplified sequences of the MDM2 and CDK4 genes. MDM2 and CDK4 protein overexpression have also been identified in these tumours.
Publication
Journal of clinical pathology, 2009, Vol 62, Issue 12, p1127