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- Title
V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours.
- Authors
Agaimy, A; Terracciano, L M; Dirnhofer, S; Tornillo, L; Foerster, A; Hartmann, A; Bihl, M P
- Abstract
A small subset (10-15%) of gastrointestinal stromal tumours (GISTs) lack mutations in KIT and PDGFRA (wild-type GIST). Recently, a novel BRAF exon 15 mutation (V600E) was detected in imatinib-naive wild-type high-risk intestinal GISTs (4%). However, the frequency and distribution of BRAF mutations within the spectrum of GISTs, and whether they might represent secondary events acquired during tumour progression, remain unknown.
- Publication
Journal of clinical pathology, 2009, Vol 62, Issue 7, p613
- ISSN
1472-4146
- Publication type
Journal Article
- DOI
10.1136/jcp.2009.064550