We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs.
- Authors
Wong, C W; Fan, Y S; Chan, T L; Chan, A S W; Ho, L C; Ma, T K F; Yuen, S T; Leung, S Y; Cancer Genome Project
- Abstract
Malignant melanoma arising from different body compartments may be associated with differing aetiological factors and clinical behaviour, and may manifest diverse molecular genetic profiles. Although many studies have focused on cutaneous melanoma, little is known of mucosal and other types of melanoma. In particular, malignant melanoma of soft parts is different from other melanomas in many respects, yet manifests a common melanocytic differentiation. Mutation of BRAF is now known to be common in cutaneous melanomas, and raises possible new therapeutic options of anti-RAF treatment for these patients. Few data are available for non-cutaneous melanomas.
- Publication
Journal of clinical pathology, 2005, Vol 58, Issue 6, p640
- ISSN
0021-9746
- Publication type
Journal Article
- DOI
10.1136/jcp.2004.022509