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- Title
Use of troponin to diagnose periprocedural myocardial infarction: effect on composite endpoints in the British Bifurcation Coronary Study (BBC ONE).
- Authors
Cockburn, James; Behan, Miles; de Belder, Adam; Clayton, Tim; Stables, Rod; Oldroyd, Keith; Curzen, Nick; Hildick-Smith, David
- Abstract
Periprocedural myocardial infarction (PMI; ESC/ACC type 4a) is diagnosed on the basis of elevation of cardiac enzymes more than three times the 99th centile upper reference limit. Recent guidelines recommend the use of troponin instead of creatine kinase (CK) to diagnose PMI, but this assay increases diagnostic sensitivity, while the clinical significance of small increases in troponin remains undetermined. We examined the effects of using the new definition on the incidence of a composite endpoint (previously defined by CK) in a contemporary clinical randomised trial-the British Bifurcation Coronary Study (BBC ONE).
- Publication
Heart (British Cardiac Society), 2012, Vol 98, Issue 19, p1431
- ISSN
1468-201X
- Publication type
Journal Article
- DOI
10.1136/heartjnl-2012-302211