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- Title
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.
- Authors
Jacobetz, Michael A; Chan, Derek S; Neesse, Albrecht; Bapiro, Tashinga E; Cook, Natalie; Frese, Kristopher K; Feig, Christine; Nakagawa, Tomoaki; Caldwell, Meredith E; Zecchini, Heather I; Lolkema, Martijn P; Jiang, Ping; Kultti, Anne; Thompson, Curtis B; Maneval, Daniel C; Jodrell, Duncan I; Frost, Gregory I; Shepard, H M; Skepper, Jeremy N; Tuveson, David A
- Abstract
Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan (HA), as a novel therapeutic target in PDA.
- Publication
Gut, 2013, Vol 62, Issue 1, p112
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gutjnl-2012-302529