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- Title
Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II.
- Authors
Schmitz, Frederike; Tjon, Jennifer M L; Lai, Yuching; Thompson, Allan; Kooy-Winkelaar, Yvonne; Lemmers, Richard J L F; Verspaget, Hein W; Mearin, M Luisa; Staal, Frank J; Schreurs, Marco W; Cupedo, Tom; Langerak, Anton W; Mulder, Chris J; van Bergen, Jeroen; Koning, Frits
- Abstract
Refractory coeliac disease type II (RCDII) is a severe complication of coeliac disease (CD) characterised by aberrant intraepithelial lymphocytes (IELs) of unknown origin that display an atypical CD3(-)CD7(+)icCD3(+) phenotype. In approximately 40% of patients with RCDII these lymphocytes develop into an invasive lymphoma. In the current study we aimed to identify the physiological counterpart of these cells.
- Publication
Gut, 2013, Vol 62, Issue 4, p509
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gutjnl-2012-302265