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- Title
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.
- Authors
Deng, Niantao; Goh, Liang Kee; Wang, Hannah; Das, Kakoli; Tao, Jiong; Tan, Iain Beehuat; Zhang, Shenli; Lee, Minghui; Wu, Jeanie; Lim, Kiat Hon; Lei, Zhengdeng; Goh, Glenn; Lim, Qing-Yan; Tan, Angie Lay-Keng; Sin Poh, Dianne Yu; Riahi, Sudep; Bell, Sandra; Shi, Michael M; Linnartz, Ronald; Zhu, Feng; Yeoh, Khay Guan; Toh, Han Chong; Yong, Wei Peng; Cheong, Hyun Cheol; Rha, Sun Young; Boussioutas, Alex; Grabsch, Heike; Rozen, Steve; Tan, Patrick
- Abstract
Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most prevalent molecular targets in gastric cancer and to elucidate systematic patterns of exclusivity and co-occurrence among these targets, through comprehensive genomic analysis of a large panel of gastric cancers.
- Publication
Gut, 2012, Vol 61, Issue 5, p673
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gutjnl-2011-301839