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- Title
TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression.
- Authors
Sillars-Hardebol, Anke H; Carvalho, Beatriz; Tijssen, Marianne; Beliën, Jeroen A M; de Wit, Meike; Delis-van Diemen, Pien M; Pontén, Fredrik; van de Wiel, Mark A; Fijneman, Remond J A; Meijer, Gerrit A
- Abstract
Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q amplicon may drive carcinogenesis. The aim of this study was to identify genes located on the 20q amplicon that promote progression of colorectal adenoma to carcinoma.
- Publication
Gut, 2012, Vol 61, Issue 11, p1568
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gutjnl-2011-301153