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- Title
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
- Authors
Gopinathan, Aarthi; Denicola, Gina M; Frese, Kristopher K; Cook, Natalie; Karreth, Florian A; Mayerle, Julia; Lerch, Markus M; Reinheckel, Thomas; Tuveson, David A
- Abstract
The lysosomal protease cathepsin B is upregulated in human pancreatic ductal adenocarcinoma (PDA) and represents a potential therapeutic target. Loss of cathepsin B delays tumour progression in mouse models of islet, mammary and intestinal carcinoma and decreases invasion and metastasis. This study examines the role of cathepsin B in the initiation, progression and metastasis of PDA.
- Publication
Gut, 2012, Vol 61, Issue 6, p877
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gutjnl-2011-300850