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- Title
Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis.
- Authors
Badiola, Iker; Olaso, Elvira; Crende, Olatz; Friedman, Scott L; Vidal-Vanaclocha, Fernando
- Abstract
The transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a major mechanism for stroma development in hepatic metastasis, but their regulatory pathways remain unclear. Transdifferentiated HSCs from fibrotic liver express high levels of the fibrillar collagen receptor discoidin domain receptor 2 (DDR2), but it is unclear if DDR2 plays a direct profibrogenic role in the tumour microenvironment.
- Publication
Gut, 2012, Vol 61, Issue 10, p1465
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gutjnl-2011-300810