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- Title
Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression.
- Authors
de Wit, Meike; Jimenez, Connie R; Carvalho, Beatriz; Belien, Jeroen A M; Delis-van Diemen, Pien M; Mongera, Sandra; Piersma, Sander R; Vikas, Maindad; Navani, Sanjay; Pontén, Fredrik; Meijer, Gerrit A; Fijneman, Remond J A
- Abstract
Early detection of colon adenomas at high risk of progression and early-stage colorectal cancer (CRC) is an effective approach to reduce CRC death rates. Current screening methods lack specificity as they detect many adenomas that will never progress to CRC. The authors aimed to identify cell surface protein biomarkers with extracellular domains that could be targeted for molecular imaging and discriminate low-risk adenomas and normal colon from high-risk adenomas and CRC.
- Publication
Gut, 2012, Vol 61, Issue 6, p855
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gutjnl-2011-300511