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Title
Antagonism of ghrelin receptor reduces food intake and body weight gain in mice.
Authors
Asakawa, A; Inui, A; Kaga, T; Katsuura, G; Fujimiya, M; Fujino, M A; Kasuga, M
Abstract
Ghrelin, an endogenous ligand for growth hormone secretagogue receptor (GHS-R), is an appetite stimulatory signal from the stomach with structural resemblance to motilin. We examined the effects of the gastric peptide ghrelin and GHS-R antagonists on energy balance and glycaemic control in mice.