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- Title
Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease.
- Authors
Keshavarzian, A; Banan, A; Farhadi, A; Komanduri, S; Mutlu, E; Zhang, Y; Fields, J Z
- Abstract
Overproduction of colonic oxidants contributes to mucosal injury in inflammatory bowel disease (IBD) but the mechanisms are unclear. Our recent findings using monolayers of intestinal cells suggest that the mechanism could be oxidant induced damage to cytoskeletal proteins. However, oxidants and oxidative damage have not been well characterised in IBD mucosa.
- Publication
Gut, 2003, Vol 52, Issue 5, p720
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.52.5.720