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- Title
Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation.
- Authors
Vaughan, R B; Angus, P W; Chin-Dusting, J P F
- Abstract
There is evidence that dampened responses to endogenous vasoconstrictors contribute to the hyperdynamic circulation that is characteristic of advanced cirrhosis. The aim of this study was to determine whether there is an altered vascular responsiveness to the endothelium derived constricting factor endothelin-1 (ET-1) in patients with decompensated chronic liver disease which might contribute to this abnormal circulatory state, and whether normal endothelin responses are restored following liver transplantation.
- Publication
Gut, 2003, Vol 52, Issue 10, p1505
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.52.10.1505