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Title
Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation.
Authors
Lyford, G L; He, C-L; Soffer, E; Hull, T L; Strong, S A; Senagore, A J; Burgart, L J; Young-Fadok, T; Szurszewski, J H; Farrugia, G
Abstract
Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation.