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- Title
Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum.
- Authors
Takayama, I; Daigo, Y; Ward, S M; Sanders, K M; Walker, R L; Horowitz, B; Yamanaka, T; Fujino, M A
- Abstract
Interstitial cells of Cajal (ICC) are pacemakers and mediators of motor neurotransmission in gastrointestinal smooth muscles. ICC require cellular signalling via Kit, a receptor tyrosine kinase, for development and maintenance of phenotype. Much of the evidence demonstrating the functions of ICC comes from studies of W/W(V) mice, which have reduced Kit function and reductions in specific populations of ICC. The aim of the present study was to differentially examine gene expression in the small intestines of wild-type and W/W(V) mutant mice.
- Publication
Gut, 2002, Vol 50, Issue 6, p790
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.50.6.790