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- Title
Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.
- Authors
Drenth, J P H; te Morsche, R; Jansen, J B M J
- Abstract
Although chronic pancreatitis is associated with risk factors such as alcoholism, hyperparathyroidism, and hypertriglyceridaemia, little is known of the actual aetiology of the disease. It is thought that inappropriate activation of trypsinogen causes pancreatitis, and indeed in cases of hereditary pancreatitis mutations of cationic trypsinogen (PRSS1) have been described. As serine protease inhibitor Kazal type 1 (SPINK1) is a potent natural inhibitor of pancreatic trypsin activity, we hypothesised that SPINK1 mutations would be more common than expected among an unselected cohort of adult chronic pancreatitis patients.
- Publication
Gut, 2002, Vol 50, Issue 5, p687
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.50.5.687