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- Title
Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis.
- Authors
Mews, P; Phillips, P; Fahmy, R; Korsten, M; Pirola, R; Wilson, J; Apte, M
- Abstract
It is now generally accepted that chronic pancreatic injury and fibrosis may result from repeated episodes of acute pancreatic necroinflammation (the necrosis-fibrosis sequence). Recent studies suggest that pancreatic stellate cells (PSCs), when activated, may play an important role in the development of pancreatic fibrosis. Factors that may influence PSC activation during pancreatic necroinflammation include cytokines known to be important in the pathogenesis of acute pancreatitis, such as tumour necrosis factor alpha (TNF-alpha), and the interleukins 1, 6, and 10 (IL-1, IL-6, and IL-10).
- Publication
Gut, 2002, Vol 50, Issue 4, p535
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.50.4.535