We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gut adaptation and the glucagon-like peptides.
- Authors
Drucker, D J
- Abstract
The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 may enhance energy absorption and reduce fluid loss in subjects with short bowel syndrome suggesting that GLP-2 functions as a key regulator of mucosal integrity, permeability, and nutrient absorption. Hence GLP-2 may be therapeutically useful in diseases characterised by injury or dysfunction of the gastrointestinal epithelium.
- Publication
Gut, 2002, Vol 50, Issue 3, p428
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.50.3.428