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- Title
Developmental aspects of human hepatic drug glucuronidation in young children and adults.
- Authors
Strassburg, C P; Strassburg, A; Kneip, S; Barut, A; Tukey, R H; Rodeck, B; Manns, M P
- Abstract
The liver represents one of the major sites of human glucuronidation. Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to the formation of usually inactive glucuronides. Hepatic glucuronidation undergoes significant changes during fetal and neonatal development requiring age adapted drug therapy. Regulation of individual UGT genes during hepatic development has not been defined.
- Publication
Gut, 2002, Vol 50, Issue 2, p259
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.50.2.259