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- Title
Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus.
- Authors
Kaneto, H; Sasaki, S; Yamamoto, H; Itoh, F; Toyota, M; Suzuki, H; Ozeki, I; Iwata, N; Ohmura, T; Satoh, T; Karino, Y; Satoh, T; Toyota, J; Satoh, M; Endo, T; Omata, M; Imai, K
- Abstract
Inactivation of the p16(INK4A) (p16) tumour suppressor gene by promoter region hypermethylation has been demonstrated not only in many types of tumours, including hepatocellular carcinoma (HCC), but also in early preneoplastic lesions in the lung, colon, oesophagus, and pancreas. The aim of this study was to examine the methylation status of the p16 promoter in pre- and/or non-neoplastic liver diseases. PATIENTS/SUBJECTS/METHODS: The methylation status of p16 was evaluated in 22 HCC, 17 cirrhosis, 17 chronic hepatitis, nine primary biliary cirrhosis (PBC), eight autoimmune hepatitis, seven drug induced liver disease, six fatty liver, and three normal liver tissues using methylation specific polymerase chain reaction (MSP). p16 protein expression was also examined by immunohistochemical staining.
- Publication
Gut, 2001, Vol 48, Issue 3, p372
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.48.3.372