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- Title
CTLA-4 gene polymorphism is associated with predisposition to coeliac disease.
- Authors
Djilali-Saiah, I; Schmitz, J; Harfouch-Hammoud, E; Mougenot, J F; Bach, J F; Caillat-Zucman, S
- Abstract
Susceptibility to coeliac disease is strongly associated with particular HLA class II alleles. However, non-HLA genetic factors are likely to be required for the development of the disease. Among candidate genes is the CTLA-4 (cytotoxic T lymphocyte associated) gene located on chromosome 2q33 in humans, which encodes a cell surface molecule providing a negative signal for T cell activation.
- Publication
Gut, 1998, Vol 43, Issue 2, p187
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.43.2.187