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Title
Activation of nuclear factor kappa B inflammatory bowel disease.
Authors
Schreiber, S; Nikolaus, S; Hampe, J
Abstract
Expression of pro-inflammatory cytokines is increased in the intestinal lamina propria of patients with inflammatory bowel disease (IBD). Nuclear factor kappa B (NF kappa B) controls transcription of inflammation genes. On activation, NF kappa B is rapidly released from its cytoplasmic inhibitor (I kappa B), transmigrates into the nucleus, and binds to DNA response elements in gene promoter regions.