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Title
Expression of arylamine N-acetyltransferase in human intestine.
Authors
Hickman, D; Pope, J; Patil, S D; Fakis, G; Smelt, V; Stanley, L A; Payton, M; Unadkat, J D; Sim, E
Abstract
Arylamine N-acetyltransferases in humans (NAT1 and NAT2) catalyse the acetylation of arylamines including food derived heterocyclic arylamine carcinogens. Other substrates include the sulphonamide 5-aminosalicylic acid (5-ASA), which is an NAT1 specific substrate; N-acetylation of 5-ASA is a major route of metabolism. NAT1 and NAT2 are both polymorphic.