We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of omeprazole and cimetidine on prepyloric gastric ulcer: double blind comparative trial.
- Authors
Lauritsen, K; Rune, S J; Wulff, H R; Olsen, J H; Laursen, L S; Havelund, T; Astrup, L; Bendtsen, F; Linde, J; Bytzer, P
- Abstract
We conducted a six week double blind randomised study of 176 patients with prepyloric gastric ulcer to determine whether the proton pump inhibitor, omeprazole 30 mg daily would accelerate healing and pain relief, as compared with cimetidine 1 g daily. At two, four, and six weeks after entry ulcers healed in a larger percentage of patients treated with omeprazole (54, 81, and 86%) than of those treated with cimetidine (39, 73, and 78%) ('intention to treat' cohort; p less than 0.05 at two weeks). A higher proportion of patients on omeprazole became free of pain during the first week of treatment (p less than 0.05). No major clinical or biochemical side effects were noted. Omeprazole is an efficient treatment for patients with prepyloric gastric ulcers.
- Publication
Gut, 1988, Vol 29, Issue 2, p249
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.29.2.249