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- Title
Treatment of hepatic encephalopathy with metronidazole.
- Authors
Morgan, M H; Read, A E; Speller, D C
- Abstract
Neomycin, an antibiotic which is primarily active against the aerobic gut flora and hence reduces the endogenous production of ammonia, is a well-recognised form of treatment for acute or acute on chronic hepatic encephalopathy. This study suggests that metronidazole may be a useful alternative or even adjunctive treatment for such patients. Theoretical and practical justifications for the use of this drug are presented. The results of a week's prescription of each drug have been assessed by changes in clinical and biochemical criteria, including electroencephalograms and arterial ammonia sample. In the treatment of a series of 11 mildly or moderately, and seven severely affected, patients with histologically confirmed cirrhosis, metronidazole is shown to be as effective as neomycin.
- Publication
Gut, 1982, Vol 23, Issue 1, p1
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.23.1.1