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- Title
The NSAID sulindac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon.
- Authors
Mladenova, Dessislava; Daniel, Joseph J; Dahlstrom, Jane E; Bean, Elaine; Gupta, Ruta; Pickford, Russell; Currey, Nicola; Musgrove, Elizabeth A; Kohonen-Corish, Maija R J
- Abstract
The non-steroidal anti-inflammatory drug sulindac is an effective chemopreventive agent in sporadic colorectal cancer but its potential benefit in mismatch repair deficient cancers remains to be defined. We wanted to determine whether genetic defects that are relevant for colorectal cancer, such as Msh2 or p53 deficiency, would influence the efficiency of sulindac chemoprevention or increase the side effects.
- Publication
Gut, 2011, Vol 60, Issue 3, p350
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2010.208314