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- Title
Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.
- Authors
Han, Xiaonan; Gilbert, Shila; Groschwitz, Katherine; Hogan, Simon; Jurickova, Ingrid; Trapnell, Bruce; Samson, Charles; Gully, Jonathan
- Abstract
Administration of granulocyte-macrophage colony stimulating factor (GM-CSF) relieves symptoms in Crohn's disease (CD). It has been reported that reduced GM-CSF bioactivity is associated with more aggressive ileal behaviour and that GM-CSF-null mice exhibit ileal barrier dysfunction and develop a transmural ileitis following exposure to non-steroidal anti-inflammatory drugs (NSAIDs). STAT5 signalling is central to GM-CSF action. It was therefore hypothesised that GM-CSF signalling in non-haematopoietic cells is required for ileal homeostasis.
- Publication
Gut, 2010, Vol 59, Issue 8, p1066
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2009.203893