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- Title
Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers.
- Authors
Svrcek, Magali; Buhard, Olivier; Colas, Chrystelle; Coulet, Florence; Dumont, Sylvie; Massaoudi, Illiasse; Lamri, Amel; Hamelin, Richard; Cosnes, Jacques; Oliveira, Carla; Seruca, Raquel; Gaub, Marie-Pierre; Legrain, Michèle; Collura, Ada; Lascols, Olivier; Tiret, Emmanuel; Fléjou, Jean-François; Duval, Alex
- Abstract
O(6)-Methylguanine-DNA methyltransferase (MGMT) removes methyl adducts from O(6)-guanine. Known as methylation tolerance, selection for mismatch repair (MMR)-deficient cells that are unable to initiate lethal processing of O(6)-methylguanine-induced mismatches in DNA is observed in vitro as a consequence of MGMT deficiency. It was therefore hypothesised that an MGMT field defect may constitute a preneoplastic event for the development of MMR-deficient tumours displaying microsatellite instability (MSI).
- Publication
Gut, 2010, Vol 59, Issue 11, p1516
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2009.194787