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Title
Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer.
Authors
Schernhammer, Eva S; Giovannucci, Edward; Kawasaki, Takako; Rosner, Bernard; Fuchs, Charles S; Ogino, Shuji
Abstract
Although critical for methylation reactions, how dietary folate and B vitamins affect global DNA methylation level in colorectal cancers is currently unknown. Long interspersed nucleotide element-1 (LINE-1) is an emerging indicator of genome-wide DNA methylation level that has previously been linked to colon cancer survival.