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- Title
Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells.
- Authors
Iliev, I D; Spadoni, I; Mileti, E; Matteoli, G; Sonzogni, A; Sampietro, G M; Foschi, D; Caprioli, F; Viale, G; Rescigno, M
- Abstract
In mice, a subpopulation of gut dendritic cells (DCs) expressing CD103 drives the development of regulatory T (T(reg)) cells. Further, it was recently described that the cross-talk between human intestinal epithelial cells (IECs) and DCs helps in maintaining gut immune homeostasis via the induction of non-inflammatory DCs. In this study, an analysis was carried out to determine whether IECs could promote the differentiation of CD103+ tolerogenic DCs, and the function of primary CD103+ DCs isolated from human mesenteric lymph nodes (MLNs) was evaluated.
- Publication
Gut, 2009, Vol 58, Issue 11, p1481
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2008.175166