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- Title
Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study.
- Authors
Tjonneland, A; Overvad, K; Bergmann, M M; Nagel, G; Linseisen, J; Hallmans, G; Palmqvist, R; Sjodin, H; Hagglund, G; Berglund, G; Lindgren, S; Grip, O; Palli, D; Day, N E; Khaw, K-T; Bingham, S; Riboli, E; Kennedy, H; Hart, A; IBD in EPIC Study Investigators
- Abstract
Dietary linoleic acid, an n-6 polyunsaturated fatty acid, is metabolised to arachidonic acid, a component of colonocyte membranes. Metabolites of arachidonic acid have pro-inflammatory properties and are increased in the mucosa of patients with ulcerative colitis. The aim of this investigation was to conduct the first prospective cohort study investigating if a high dietary intake of linoleic acid increases the risk of developing incident ulcerative colitis.
- Publication
Gut, 2009, Vol 58, Issue 12, p1606
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2008.169078