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- Title
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
- Authors
Festen, E A M; Goyette, P; Scott, R; Annese, V; Zhernakova, A; Lian, J; Lefèbvre, C; Brant, S R; Cho, J H; Silverberg, M S; Taylor, K D; de Jong, D J; Stokkers, P C; Mcgovern, D; Palmieri, O; Achkar, J-P; Xavier, R J; Daly, M J; Duerr, R H; Wijmenga, C; Weersma, R K; Rioux, J D
- Abstract
Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn's disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac disease, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and psoriasis), while the roles that interleukin 2 (IL2) and IL21 play in the immune response also make them attractive candidates for IBD. The objective of this study was to test for association between the IL2/IL21 locus and the IBDs.
- Publication
Gut, 2009, Vol 58, Issue 6, p799
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2008.166918