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- Title
A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.
- Authors
Keywood, C; Wakefield, M; Tack, J
- Abstract
In preclinical models, antagonism of metabotropic glutamate receptor 5 (mGluR5) reduces transient lower oesophageal sphincter relaxations (TLOSRs) and increases LOS pressure. This study evaluated the effect of ADX10059, a potent, selective, negative allosteric modulator of mGluR5, on oesophageal pH-metry and clinical symptoms in GORD.
- Publication
Gut, 2009, Vol 58, Issue 9, p1192
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2008.162040