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- Title
Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats.
- Authors
Melgar-Lesmes, P; Tugues, S; Ros, J; Fernández-Varo, G; Morales-Ruiz, M; Rodés, J; Jiménez, W
- Abstract
The extent and molecular mechanisms governing plasma extravasation and formation of ascites in cirrhosis are unknown. Vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Ang-2) are endogenous substances with powerful vascular permeability effects. We assessed regional blood flow, vascular leakage, mRNA and tissular expression of VEGF-A and Ang-2 and vascular permeability following VEGF receptor 2 blockade in control and cirrhotic rats to define the vascular territories showing altered vascular permeability in cirrhosis and to determine whether VEGF-A and Ang-2 are involved in this phenomenon.
- Publication
Gut, 2009, Vol 58, Issue 2, p285
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2008.155028